HADD-ADHD Ireland along with the CoCA EU Project and Trinity College hosted an event on ‘Adults and ADHD’.

HADD-ADHD Ireland along with the CoCA EU Project and Trinity College are delighted to announce a FREE talk on ‘Adults and ADHD’, which will be held Tuesday 20^th March, 7.00pm – 9.30pm. Take a look at the Flyer for more information.

The recruitment for the PROUD study within CoCA is ongoing. If you are interested in taking part take a look at these recruitement flyers from our recruitment sites in Germany (adults, adolescents), UK, Spain and the Netherlands and get in contact with them.

You can see Oliver Grimm from CoCA Coordinator GUF talk ADHD, obesity and the reward system in newly uploaded CoCA webinar.

Meet CoCA’s early career researchers Elena Koch from the Karlsruhe Institute of Technology and Nina Roth Mota from  the Radboud University Medical Center.

Jeanette Mostert, part of the CoCA team at RUMC, took on the challenge to explain CoCA using only the 1,000 most common words used in the English language (thanks to: http://splasho.com/upgoer5/).​ This may not capture all the details of the project, but should give you a general impression of what our research is about.

‘We study why people who can’t sit still and pay attention also often feel sad, or eat too much, or use too much of things that are not good for them and can’t stop with it. They have these problems more often than people who are better at sitting still and paying attention, and the problems get worse when they become older. We think that this is because their brain works a bit different. We try to help them by making them jump and run every day, and by giving them more light. And we give them a phone to show them what they should do, and how good they are doing each day. The jumping and running and more light each day should make them more happy. We also look in their brains for things that cause both not sitting still and eating too much, or not paying attention and feeling sad. When we understand better how these things in our brains can cause these problems, we can help the people who have these problems to get better.’

To download the CoCA poster and flyer, click on the links.

Aggressotype researchers (incl. CoCA members) together with the patient organisation ADHD Europe defined patient-friendly dissemination guidelines for Aggressotype and CoCA research (Click here to download the dissemination guidelines).

Meet CoCA’s Early Career Researchers Elena Koch (KIT) and Nina Roth Mota (RUMC):

Various ‘Ask the ADHD Experts’ sessions have been added to the ‘ADHD in Adults’ website, incl. session by CoCA partners on ‘ADHD and Bipolar Disorder’ (Andreas Reif, GUF), ‘ADHD and emotional dysregulation’ (Philip Asherson, KCL), ‘medical treatment of young ADHD prisoners’ (Philip Asherson, KCL), and ‘ADHD – Facts and Fiction’ (Stephen Faraone, SUNY). Click here to subscribe and watch the session.

In Episode 2 of ENIGMA’s interview series, ENIGMA-ADHD chairs Martine Hoogman and Barbara Franke (RUMC) discuss their recent work published in The Lancet Psychiatry. Their findings show structural differences in subcortical brain regions in MRIs of patients with ADHD.

Recent contributions by Prof Reif in German media: Click here

How bright light and physical exercise might help ADHD patients
by Thomas Wagner-Nagy (concentris)

Attention deficit hyperactivity disorder (ADHD) is a mental health condition that rarely occurs alone. More than 80 percent of adult ADHD patients suffer from a comorbid disorder, meaning there is at least one additional disease co-occuring with the primary disease.
In the case of ADHD, two common comorbid conditions are obesity and major depressive disorder, Therefore, the risk for comorbid obesity and major depressive disorder is increased in adolescents and adults with ADHD. Moreover, a disturbed circadian rhythm and altered sleep are key features of ADHD.
Bright light therapy, a so-called chronobiological modification, improves the day-night (circadian) rhythm and is an established therapy for major depression in adolescents and adults. Exercise prevents and reduces obesity in adolescents and adults along with improving depressive symptoms.
While these non-pharmacologic treatments are known to modulate dopaminergic transmission (DA) and circadian rhythm (CIRCA), two key mechanisms regulating mental wellbeing, no study has assessed their effect on ADHD and its comorbidities in an experimental setting yet. PROUD is therefore the first large scale, multicentre study to systematically evaluate the role of DA and CIRCA and scrutinize their potential relevance for developing disease biomarkers and thus obtaining measurable indicators for predicting and treating these ADHD comorbidities.
“The idea here is to employ non-pharmacological methods to improve patients’ lives. There is a well established drug treatment for ADHD with stimulants – methylphenidate being the most famous one. However, that is only one step and we want to make use of the knowledge that sports on the one hand and bright light therapy on the other hand showed promising initial data to improve patients’ lives with ADHD”, says CoCA project coordinator Andreas Reif, Chair of the Department of Psychiatry, Psychosomatic Medicine and Psychotherapy at the University Hospital Frankfurt in Germany.
“So we put that into a clinical study where we compared treatment as usual with add-on sports therapy or add-on bright light therapy. Over this ten-week trial, we will see whether this affects not only ADHD symptoms but overall health symptoms like depressive symptoms or weight.”

Need a watchdog or motivator? There’s an app for that
Just how do you motivate obese patients to exercise regularly? “It’s very hard to get up and do sports on a daily basis”, says Reif. “We thought about how we can empower our patients to adhere to the study protocol. In order to do that, we have developed a mobile health application, the mHealth App.”
The mHealth App was specifically developed for the PROUD Study with the aim of keeping the patients motivated. “We achieve this by showing them videos of exercise, sending reminders as well as a daily feedback and summary on their achievements”, trial coordinator Jutta Mayer explains.

The study has started with its first participants at the University Hospital of Frankfurt in late March 2017. The CoCA team expects first results and insights by the end of 2017.

PDF: CoCA Press Release_PROUD study has started

Prof. Dr. Barbara Franke was invited to become a member of the Royal Netherlands Academy of Arts and Sciences (KNAW).
The Academy is an organization dedicated to the advancement of science and literature in the Netherlands. In addition to various advisory and administrative functions it operates a number of research institutes and awards many prizes. The Academy is an important advisory organ to the Dutch government on scientific matters; it offers solicited and unsolicited advice to parliament, ministries, universities and research institutes, funding agencies, and international organizations. The members are appointed for life by co-optation. The acceptance criterion is delivered scientific achievements.
The invitation to join KNAW comes only two months after Barbara Franke’s installation as an elected member at the second scientific Royal Society in The Netherlands, the Royal Holland Society of Sciences and Humanities (KHMW).

During the World Congress on ADHD in Vancouver, CoCA representatives sat together for a Round Table with the industry (Shire, Medice, Nesplora, NeuroConn and SFI).

A paper by Martine Hoogman from CoCA partner RUMC on ‘Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults‘ has led to wide media feedback, which will hopefully help to reduce the stigma still attached to the disorder. The paper was covered by CNN, CBS, The Time Magazine and many more.  Click here to see the a list of news reports.

A poster with general information on CoCA is now available: Click here to download it

CoCA’s first webinar featuring Prof. Philip Asherson (King’s College London) talking about ‘ADHD and its comorbidities from a clinician’s perspective’ is now online.

Prof. Andreas Reif, coordinator of the CoCA project gave a talk on ‘The development of the clinical presentation of ADHD through the lifespan’ at ECNP 2016 (17-20/09/2016, Vienna). Click here to watch the talk.

A second talk was given by J. Antoni Ramos-Quiroga on ‘Emotinal lability: its value in the differential diagnosis and treatment of ADHD’.

Click here to watch the talk.

ADHD-Europe, with whom CoCA closely collaborates, have launched a declaration about ADHD across the lifespan and the need of continued treatment. We would like to encourage you to sign their declaration in support at: http://www.adhdeurope.eu/adhd-europe/adhd-declaration-2016.html

A kick-off meeting was organized in Frankfurt, Germany for CoCA’s randomized, single-blinded, controlled study. The aim of this meeting was to allow for a standardized conduct of the study at all clinical sites (GUF, VHIR-BCN, KCL, and RUMC). Therfore, talks were given on e.g. data management and monitoring and workshops were held on using the m-Health system, the Bright Light Therapy, and assesing body measures in the course of the PROUD study.

 

Prof . Jan Haavik from the University of Beregn received the Helse Vests research award for his work on the molecular underpinnings of ADHD. The whole CoCA consortium congratulates him on this achievement.

With an inspiring three-day meeting, the international research project ‘Comorbid Conditions in ADHD’ (CoCA) was successfully kicked-off in Frankfurt on March 1 to 3. The CoCA programme is a new EU-funded project on biological mechanisms shared by attention-deficit/hyperactivity (ADHD) and several of its most frequent psychiatric and somatic comorbidities, i.e. anxiety/depression, substance use disorders, and obesity.

In fierce competition, the CoCA project was selected for funding from over 300 submitted proposals, together with only six others. CoCA will receive 6 Mio Euro for research from the European Commission during the next 5 years. This funding will provide the 17 partners from 8 European countries and the US with the opportunity to investigate the role of dopamine neurotransmission and the circadian rhythm machinery (as well as additional relevant biological processes to be identified as part of CoCA) in the co-occurrence of the different disorders. In addition, they will perform randomized clinical trials for two non-pharmacological, inexpensive, and easy accessible interventions, i.e. physical exercise and bright light therapy, to study their potential to prevent ADHD comorbidity.

In stimulating and fruitful discussions, the 45 meeting delegates finalized plans for a total of 11 comprehensive and highly complementary work packages during the Kick-off meeting. Amongst the project partners are also a representative of the European patient support group ADHD-Europe, which will actively contribute to research and dissemination of CoCA and US-based and German leading experts, who form the Scientific and Ethics Advisory Board of CoCA.

More than 21 million people suffer from ADHD in the EU, with direct medical cost and loss due to decreased productivity adding up to over €70 billion per year. ADHD, being a childhood-onset disorder, forms the entry route into a (preventable) negative developmental trajectory later in life; importantly, more than 80% of adult ADHD patients suffer from a comorbid disorder. However, exact numbers of ADHD patients suffering from the comorbidities under study is not yet available. CoCA will provide such information, based on large epidemiological data sets, and – for the first time – will calculate the costs associated with such comorbidity. Through the research approaches taken in CoCA, we hope to raise awareness for ADHD, reduce the stigma associated with this disorder, and empower prevention and therapy approaches.

The CoCA programme is coordinated by Prof. Andreas Reif from the Goethe University in Frankfurt, Germany.